The year round service will commence on 7 September and will offer up to three daily flights departing early morning, lunchtime and late afternoons.
The flights have been timed to coincide with many convenient onward long-haul connections that are available through Amsterdam with destinations including New York, Bangkok, Singapore, Hong Kong, Tokyo, Shanghai and Toronto.
Flybe’s chief commercial officer, Paul Simmons, said: "Flybe is delighted to play a part in making it possible for Liverpool customers to access the world through Amsterdam and, just as importantly, make it easier for the rest of the world to come to Liverpool. The airline already has a number of codeshare and interline arrangements with long haul carriers that in the future has the potential to benefit passengers even further."
Liverpool Airport CEO Andrew Cornish added: "The importance of this route should not be underestimated and this is a big commitment by Flybe and the news will be welcomed by the region’s business and leisure travellers. This is the most frequently requested route by stakeholders from across the region who recognise the strategic importance of this link. It will also bring a further boost for the region’s tourism offer and inward investment opportunities."
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